Osteoarthritis disorders (OADs) occur in knee-joints, lumbar, cervical and hip regions. Globally, these diseases are major health concerns. These occur due to age, obesity, injury affecting muscles and bones, working posture etc. The objective is to develop the tools for pain diagnosis and prevention for OADs and normalization by topical phytotherapeutic protocol with specialised treatment. The present results indicate a pioneering study for new pain diagnostic parameters for complete recovery of knee osteoarthritis and prevention of early stage of osteoarthritic disorder in knee-joint by phototherapeutic protocol as evidenced by anatomical observations, biochemical profiles and radiographic data.